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货号： bs-13743R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13743R-PE-Cy7
- 英文名称
- Anti-CTNNA3/PE-Cy7
- 中文名称
- PE-Cy7标记的钙粘蛋白相关蛋白CTNNA3抗体
- 别 名
- 4930429L08Rik; 4933408A16; Alpha catenin like protein; Alpha T catenin; Alpha T-catenin; Cadherin associated protein; Cadherin-associated protein; Catenin alpha 3; Catenin alpha-3; Catna3; CTNA3_HUMAN; CTNNA3; MGC26194; MGC75041; OTTHUMP00000019684; OTTMUSP00000028119; OTTMUSP00000028120; RP11-433J16.1; VR22.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 细胞粘附分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 100kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CTNNA3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The catenins are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantally expressed in cardiomyocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimers disease (LOAD) as well as to dilated cardiomyopathy.
Function:
May be involved in formation of stretch-resistant cell-cell adhesion complexes.
Subcellular Location:
Cytoplasm; cytoskeleton. Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2.
Tissue Specificity:
Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle.
Similarity:
Belongs to the vinculin/alpha-catenin family.
Database links:Entrez Gene: 29110Human
Entrez Gene: 29119Human
Entrez Gene: 216033Mouse
Entrez Gene: 361839Rat
Omim: 607667Human
SwissProt: Q9UHD2Human
SwissProt: Q9UI47Human
SwissProt: Q65CL1Mouse
Unigene: 660362Human
Unigene: 444692Mouse
Unigene: 223553Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.