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货号： bs-13750R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13750R-PE-Cy7
- 英文名称
- Anti-Claudin 18/PE-Cy7
- 中文名称
- PE-Cy7标记的紧密连接蛋白18抗体
- 别 名
- Claudin 18; Claudin-18; CLD18_HUMAN; CLDN18; SFTA5; SFTPJ.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 转运蛋白 细胞粘附分子 内皮细胞 跨膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Rat, Pig, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 28kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Claudin 18
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge (5).Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (6).
Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular Location:
Cell junction > tight junction. Cell membrane.
Tissue Specificity:
Concentrated at the cell-cell borders of epithelial cells.
Similarity:
Belongs to the claudin family.
Database links:Entrez Gene: 51208Human
Entrez Gene: 56492Mouse
Entrez Gene: 315953Rat
Omim: 609210Human
SwissProt: P56856Human
SwissProt: P56857Mouse
SwissProt: D3ZLY1Rat
Unigene: 655324Human
Unigene: 386784Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.