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货号： bs-13712R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13712R-PE-Cy7
- 英文名称
- Anti-TIN-Ag/PE-Cy7
- 中文名称
- PE-Cy7标记的肾小管间质肾炎抗原抗体
- 别 名
- TINAG; TIN AG; TIN-Ag; TIN1; TIN2; TINAG; TINAG_HUMAN; Tubulointerstitial nephritis antigen.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 55kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TIN-Ag
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.
Function:
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.
Subcellular Location:
Secreted; extracellular space; extracellular matrix; basement membrane.
Tissue Specificity:
Expressed in the kidney cortex, small intestine and cornea.
Post-translational modifications:
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
DISEASE:
Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule.
Similarity:
Belongs to the peptidase C1 family.
Contains 1 SMB (somatomedin-B) domain.
Database links:Entrez Gene: 27283Human
Omim: 606749Human
SwissProt: Q9UJW2Human
Unigene: 127011Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肾小管间质性肾炎抗原(tubulointerstitial nephritis antigen,TINag)是一种主要表达在肾脏近曲小管基底膜,少部分表达在远端小管和鲍曼囊以及肠黏膜基底膜的膜糖蛋白,TINag与Ⅳ型胶原蛋白和层粘连蛋白等细胞外基质具有较高的亲和力,对维持小管基底膜的结构与功能具有重要作用.