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货号： bs-13678R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13678R-PE-Cy7
- 英文名称
- Anti-RUSC2/PE-Cy7
- 中文名称
- PE-Cy7标记的RUSC2抗体
- 别 名
- RUSC2_HUMAN; Iporin; Interacting protein of Rab1; RUN and SH3 domain-containing protein 2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 161kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RUSC2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
RUSC2 is a 1,516 amino acid cytoplasmic protein that is widely expressed, with highest levels in brain and testis. The RUN domain of RUSC2 is required for interaction with Rab 1A, Rab 1B and GM130. It is thought that RUSC2 may possibly function as a connector between endoplasmic reticulum (ER) derived vesicle targets triggered by the Rab 1 GTPases and a signaling pathway regulated by molecules containing SH3 and/or poly-proline regions. RUSC2 also consists of a SH3 domain, suggesting a role in protein-protein interactions. RUSC2 is encoded by a gene located human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.
Subunit:
Interacts with active RAB1A and RAB1B, and with GOLGA2.
Subcellular Location:
Cytoplasm; cytosol. Cytosolic punctate distribution. Also observed in the perinuclear region.
Tissue Specificity:
Widely expressed, with highest levels in brain and testis.
Similarity:
Contains 1 RUN domain.
Contains 1 SH3 domain.
Database links:Entrez Gene: 9853Human
Omim: 611053Human
SwissProt: Q8N2Y8Human
Unigene: 493796Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.