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货号： bs-13648R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13648R-PE-Cy7
- 英文名称
- Anti-JIP3/PE-Cy7
- 中文名称
- PE-Cy7标记的丝裂原活化蛋白激酶相互作用蛋白3抗体
- 别 名
- C-jun-amino-terminal kinase-interacting protein 3; FLJ00027; Homolog of Drosophila Sunday driver 2; JIP-3; JIP3_HUMAN; JNK / Stress Activated Protein Kinase Associated Protein 1; JNK Interacting Protein 3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; KIAA1066; MAPK8IP3; Mitogen Activated Protein kinase 8 Interacting Protein 3; Mitogen-activated protein kinase 8-interacting protein 3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 神经生物学 信号转导 激酶和磷酸酶 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 147kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human JIP3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The JNK-interacting proteins (JIPs) are a family of scaffold proteins that mediate JNK signaling by organizing specific components of the MAPK cascade together to form a functional JNK signaling molecule. JIP-3 (JNK-interacting protein 3), also known as JSAP1 or MAPK8IP3 (Mitogen-activated protein kinase 8-interacting protein 3), is a 1,336 amino acid protein that localizes to the cytoplasm and belongs to the JIP family. Expressed in a variety of tissues, including brain and heart, JIP-3 forms homo- or heterooligomeric complexes that can interact with several components of the JNK signaling pathway, thereby functioning as a regulator of kinesin-dependent axonal transport that may also play a role in scaffold formation within neuronal cells. Human JIP-3, which may be phosphorylated upon DNA damage, shares 69% similarity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of JIP-3 exist due to alternative splicing events.
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interations
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the JIP scaffold family.
Database links:Entrez Gene: 23162Human
Entrez Gene: 30957Mouse
Omim: 605431Human
SwissProt: Q9UPT6Human
SwissProt: Q9ESN9Mouse
Unigene: 207763Human
Unigene: 43081Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.