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货号： bs-13626R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13626R-PE-Cy7
- 英文名称
- Anti-CED6/PE-Cy7
- 中文名称
- PE-Cy7标记的细胞死亡同源蛋白6抗体
- 别 名
- CED 6; Cell death protein 6 homolog; Engulfment adapter protein; Engulfment adaptor PTB domain containing 1; GULP; GULP, engulfment adaptor PTB domain containing 1; GULP1; GULP1_HUMAN; Protein GULP; PTB domain adapter protein CED 6; PTB domain adapter protein CED-6; PTB domain adaptor protein CED6; PTB domain-containing engulfment adapter protein 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞凋亡 细胞周期蛋白 细胞分化
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 34kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CED6
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Several proteins involved in regulating and executing programmed cell death have been identified in C. elegans. CED-3, a member of the ICE protease/caspase family, and CED-4, a homolog of the mammalian Apaf-1, promote apoptosis. CED-9, a homolog of the mammalian Bcl-2 protein, inhibits cell death. EGL-1 and CED-6 both function as death-promoting proteins, with CED-6 playing a role in the engulfment of apoptotic cells. CED-5 and CED-7 are C. elegans orthologs of the mammalian DOCK180 and ABC transporter proteins, respectively, and also play a role in the engulfment of dying cells.
Function:
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Subcellular Location:
Cytoplasm. May associate with the cytoplasmic side of the plasma membrane and early endosomes.
Tissue Specificity:
Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.
Similarity:
Belongs to the ced-6 family.
Contains 1 PID domain.
Database links:Entrez Gene: 51454 Human
Entrez Gene: 70676 Mouse
Entrez Gene: 314543 Rat
Omim: 608165 Human
SwissProt: Q9UBP9 Human
SwissProt: Q8K2A1 Mouse
SwissProt: Q5PQS4 Rat
Unigene: 470887 Human
Unigene: 712910 Human
Unigene: 133132 Mouse
Unigene: 32649 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.