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货号： bs-13606R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13606R-PE-Cy7
- 英文名称
- Anti-BCL6B/PE-Cy7
- 中文名称
- PE-Cy7标记的BCL6B抗体
- 别 名
- B cell CLL/lymphoma 6, member B (zinc finger protein); B-cell CLL/lymphoma 6, member B (zinc finger protein); BAZF; Bcl6 associated zinc finger protein; Bcl6-associated zinc finger protein; ZBTB28; Zinc finger protein 62; ZNF62; BCL6B_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 干细胞 转录调节因子 淋巴细胞 b-淋巴细胞 锌指蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 51kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human BCL6B
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 ∑C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20∑C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ∑C.
- 产品介绍
- background:
Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and cell differentiation. Additionally, Bcl-6 negatively regulates NFⅹB expression, thereby inhibiting NFⅹB-mediated cellular functions. Bcl-6b (B-cell CLL/lymphoma 6, member B), also known as ZNF62, BAZF or ZBTB28, is a 480 amino acid nuclear protein that contains one BTB (POZ) domain and five C2H2-type zinc fingers. Expressed ubiquitously with highest expression in placenta and heart, Bcl-6b associates with Bcl-6 and functions as a sequence-specific transcriptional repressor that is thought to be necessary for early B-cell development. The gene encoding Bcl-6b maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
Function:
BCL6B acts as a sequence-specific transcriptional repressor in association with BCL6. It may function in a narrow stage or be related to some events in the early B-cell development.
Subcellular Location:
Nuclear
Tissue Specificity:
Ubiquitously expressed with higher expression found in heart and placenta.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 5 C2H2-type zinc fingers.
Database links:Entrez Gene: 255877Human
Omim: 608992Human
SwissProt: Q8N143Human
Unigene: 22575Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.