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货号： bs-12592R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12592R-PE-Cy7
- 英文名称
- Anti-GREM2/PE-Cy7
- 中文名称
- PE-Cy7标记的骨形态形成蛋白拮抗蛋白2抗体
- 别 名
- BMP antagonist 2; CKTSF1B2; Cysteine knot superfamily 1; Cysteine knot superfamily 1 BMP antagonist 2; DAN domain family member 3; DAND 3; DAND3; GREM 2; Grem2; GREM2_HUMAN; Gremlin 2; Gremlin 2 cysteine knot superfamily homolog; Gremlin-2; Gremlin2; PRDC; Protein related to DAN and cerberus.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 干细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 17kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GREM2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The gremlin protein family contains antagonists of bone morphogenetic protein (BMP) signaling that are expressed in the neural crest. All family members are secreted proteins that act as BMP antagonists in embryonic explants and are expressed in the proximal airway epithelium of the lung during embryonic development. Gremlin-1 is required for early limb outgrowth and patterning in the FGF4-SHH feedback loop, while gremlin-2 binds and blocks the activity of BMP-2 and BMP-4. The dorsaling factor gremlin belongs to a novel gene family that includes the head-inducing factor Cerberus and the tumor suppressor DAN. Additionally, secreted gremlin relays the sonic hedgehog signal from the polarizing region to the apical ectodermal ridge.
Function:
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells.
Subcellular Location:
Secreted.
Similarity:
Belongs to the DAN family.
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Database links:Entrez Gene: 64388Human
Entrez Gene: 23893Mouse
Omim: 608832Human
SwissProt: Q9H772Human
SwissProt: O88273Mouse
Unigene: 98206Human
Unigene: 25760Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.