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货号： bs-15588R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15588R-PE-Cy7
- 英文名称
- Anti-OAS2/PE-Cy7
- 中文名称
- PE-Cy7标记的2-5-寡腺苷酸合成酶2抗体
- 别 名
- (2-5)oligo(A) synthase 2; (2-5)oligo(A) synthetase 2; 2-5-oligoadenylate synthase 2; 2-5-oligoadenylate synthetase 2; 2-5-oligoadenylate synthetase 2, 69/71kDa; 2-5A synthase 2; 2-5A synthetase 2; MGC78578; OAS2; OAS2_HUMAN; p69 OAS / p71 OAS; p69OAS / p71OAS.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 染色质和核信号 线粒体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Dog, Pig,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 82kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human OAS2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2-specific nucleotidyl transfer reactions to synthesize 2,5-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Function:
Interferon-induced, dsRNA-activated antiviral enzymewhich plays a critical role in cellular innate antiviral response.In addition, it may also play a role in other cellular processessuch as apoptosis, cell growth, differentiation and generegulation. Synthesizes higher oligomers of 2-5-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form ofribonuclease L (RNase L) leading to its dimerization and subsequentactivation. Activation of RNase L leads to degradation of cellularas well as viral RNA, resulting in the inhibition of proteinsynthesis, thus terminating viral replication. Can mediate theantiviral effect via the classical RNase L-dependent pathway or analternative antiviral pathway independent of RNase L.[CATALYTIC ACTIVITY] 3 ATP = pppA2p5A2p5A + 2 diphosphate.
Subunit:
Homodimer.
Subcellular Location:
Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum.Note=Associated with different subcellular fractions such asmitochondrial, nuclear, and rough/smooth microsomal fractions.
Post-translational modifications:
Myristoylation is not essential for its activity.
Glycosylated. Glycosylation is essential for its activity.
Similarity:
Belongs to the 2-5A synthase family.
Database links:Entrez Gene: 4939 Human
Entrez Gene: 246728 Mouse
Omim: 603350 Human
SwissProt: P29728 Human
SwissProt: E9Q9A9 Mouse
Unigene: 414332 Human
Unigene: 260926 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.