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货号： bs-7135R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7135R-PE-Cy7
- 英文名称
- Anti-MAZ/PE-Cy7
- 中文名称
- PE-Cy7标记的锌指蛋白801抗体
- 别 名
- MAZ_HUMAN; Myc-associated zinc finger protein; MAZI; Purine-binding transcription factor; Serum amyloid A-activating factor-1; SAF-1; Transcription factor Zif87; ZF87; Zinc finger protein 801; MAZ; Pur-1; PUR1; SAF-1; SAF-2; SAF-3; ZF87; Zif87; ZNF801.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MAZ
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The Myc-associated zinc finger protein MAZ is a transcription factor that participates in both the initiation and termination of transcription of target genes. MAZ functions as a true transcriptional repressor in that it represses transcription independent of the c-Myc promoter. Both MAZ and SP1 bind to the parathyroid hormone (PTH)/ PTH-related peptide receptor promoter, thereby influencing the cell-specific expression of its gene product. MAZ and SP1 also regulate expression from the serotonin 1A receptor gene promoter, suggesting that MAZ may act on a variety of promoters through G-C rich sequences, which serve as binding sites for the SP1 family of transcription factors. Competition between SP1 and MAZ control tissue-specific expression of the PNMT gene. The interaction of MAZ with the transcriptional repressor FAC1 may affect gene regulation in neurodegeneration. MAZ also acts as a growth suppressor protein, in part by affecting the levels of key cell cycle regulatory proteins such as cyclin A and E.
Function:
May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.
Subunit:
Interacts with BPTF.
Subcellular Location:
Nucleus (Probable). Note=In brains of Alzheimer disease patients, present in a plaque-like structures.
Tissue Specificity:
Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).
Similarity:
Contains 6 C2H2-type zinc fingers.
Database links:Entrez Gene: 4150 Human
Entrez Gene: 17188 Mouse
Entrez Gene: 691842 Rat
Omim: 600999 Human
SwissProt: P56270 Human
SwissProt: P56671 Mouse
Unigene: 23650 Human
Unigene: 378964 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.