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货号： bs-15577R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15577R-PE-Cy7
- 英文名称
- Anti-IGLL1/PE-Cy7
- 中文名称
- PE-Cy7标记的免疫球蛋白lambda样肽1抗体
- 别 名
- 14.1; AGM2; CD179 antigen-like family member B; CD179B; CD179b antigen; Ig lambda 5; Ig lambda-5; IGL1; IGL5; IGLJ14.1; IGLL; Igll1; IGLL1_HUMAN; IGO; IGVPB; Immunoglobulin lambda like polypeptide 1 precursor; Immunoglobulin lambda-like polypeptide 1; Immunoglobulin omega polypeptide; Immunoglobulin omega polypeptide chain; Immunoglobulin related protein 14.1; Immunoglobulin-related protein 14.1; Lambda5; Pre B lymphocyte specific protein 2; VPREB2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 b-淋巴细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 19kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IGLL1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function:
Critical for B-cell development.
Subunit:
Associates non-covalently with VPREB1.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative).
DISEASE:
Agammaglobulinemia 2 (AGM2) [MIM:613500]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Database links:
UniProtKB/Swiss-Prot: P15814.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.