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货号： bs-15522R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15522R-PE-Cy7
- 英文名称
- Anti-phospho-IFNAR1(Tyr466) /PE-Cy7
- 中文名称
- PE-Cy7标记的磷酸化干扰素alpha/beta 受体1蛋白抗体
- 别 名
- IFNAR1 (phospho Y466); p-IFNAR1 (phospho Y466); Alpha type antiviral protein; AVP; Beta type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; IFN alpha REC; IFN alpha REC; IFN alpha receptor; IFN alpha/beta Receptor alpha; IFN beta receptor; Interferon alpha/beta receptor 1; IFN-alpha/beta receptor 1; IFN-R-1; IFNAR; IFNAR1; IFNBR; IFRC; INAR1_HUMAN; Interferon (alpha beta and omega) receptor 1; Interferon alpha/beta receptor 1; Interferon alpha/beta receptor alpha chain; Interferon beta receptor 1; Type I interferon receptor 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 染色质和核信号 信号转导 细胞因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Pig, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 61kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthesised phosphopeptide derived from human IFNAR1 around the phosphorylation site of Tyr466
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
IFNAR1 is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
Function:
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
Subunit:
Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2.
Subcellular Location:
Isoform 1: Membrane; Single-pass type I membrane protein.
Tissue Specificity:
IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
Post-translational modifications:
Phosphorylated on tyrosine residues by TYK2 tyrosine kinase.
Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.
Similarity:
Belongs to the type II cytokine receptor family.
Contains 3 fibronectin type-III domains.
Database links:Entrez Gene: 3454Human
Omim: 107450Human
SwissProt: P17181Human
Unigene: 529400Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.