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货号： bs-15532R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15532R-PE-Cy7
- 英文名称
- Anti-IBTK/PE-Cy7
- 中文名称
- PE-Cy7标记的Bruton酪氨酸激酶抑制剂蛋白抗体
- 别 名
- BTKI; IBtk; IBTK_HUMAN; inhibitor of Bruton agammaglobulinemia tyrosine kinase; Inhibitor of Bruton tyrosine kinase.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 150kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IBTK
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
IBTK is a encoded by this gene binds to Brutons tyrosine kinase (BTK) and downregulates BTKs kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
Function:
Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.
Subunit:
Interacts with the PH domain of BTK. Isoform 2 does not interact with BTK.
Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation.
Isoform 2: Nucleus.
Tissue Specificity:
Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues.
Similarity:
Contains 3 ANK repeats.
Contains 2 BTB (POZ) domains.
Contains 3 RCC1 repeats.
Database links:Entrez Gene: 25998 Human
Omim: 606457 Human
SwissProt: Q9P2D0 Human
Unigene: 306425 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.