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货号： bs-15474R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15474R-PE-Cy7
- 英文名称
- Anti-HHAT/PE-Cy7
- 中文名称
- PE-Cy7标记的T细胞2识别黑色素瘤抗原抗体
- 别 名
- 2810432O22Rik; AC115917.1; AI462858; FLJ10724; FLJ34867; Hedgehog acyltransferase; Hhat; HHAT_HUMAN; MART 2; MART-2; MART2; Melanoma antigen recognized by T cells 2; Melanoma antigen recognized by T-cells 2; MGC11697; OTTMUSP00000033669; Protein cysteine N palmitoyltransferase HHAT; Protein-cysteine N-palmitoyltransferase HHAT; RGD1311746; SKI1; Skinny hedgehog protein 1; Skinny hedgehog protein; Skn.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HHAT
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
HHAT is a 493 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and belongs to the membrane-bound acyltransferase family. Expressed ubiquitously, HHAT functions to catalyze the N-terminal palmitoylation of SSH (slingshot homolog), an event that is required for SHH signaling pathways. HHAT is expressed in cancer cell lines, suggesting a role for HHAT in tumorigenesis. The gene encoding HHAT maps to human chromosome 1 and is expressed as four alternatively spliced isoforms. Chromosome 1 is the largest human chromosome, spanning about 260 million base pairs and making up 8% of the human genome. Several disorders, including Stickler syndrome, Parkinsons Disease, Gaucher disease, malignant melanoma and Usher syndrome, are caused by defects in genes that localize to chromosome 1.
Function:
Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling (By similarity). May bind GTP.
Subcellular Location:
Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
Tissue Specificity:
Ubiquitously expressed in normal tissues and cancer cell lines.
Similarity:
Belongs to the membrane-bound acyltransferase family. HHAT subfamily.
Database links:Entrez Gene: 57467 Human
Entrez Gene: 74770 Mouse
Entrez Gene: 301073 Rat
Omim: 608116 Human
SwissProt: Q9HCP6 Human
SwissProt: Q9D1G3 Mouse
Unigene: 476041 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.