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货号： bs-15470R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15470R-PE-Cy7
- 英文名称
- Anti-HEXO/PE-Cy7
- 中文名称
- PE-Cy7标记的3-5外切酶1蛋白抗体
- 别 名
- ERI1; HEXO; THEX1; 3HEXO; ERI1 exoribonuclease 1; 3 5 exonuclease ERI 1; 3 5 exonuclease ERI1; 3 EXO; 3 exoribonuclease; 3 HEXO; 3 histone mRNA exonuclease 1; 3-5 exonuclease eri1; 3-5 exoribonuclease 1; 3EXO; 3HEXO; ERI 1; Eri 1 homolog; Eri-1 homolog; eri1; Eri1 homolog; ERI1_HUMAN; HEXO; Histone mRNA 3 end specific exonuclease; Histone mRNA 3 end specific exoribonuclease; Histone mRNA 3-end-specific exoribonuclease; Histone mRNA 3-exonuclease 1; MGC35395; Protein 3hExo; THEX 1; Three prime histone mRNA exonuclease 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 染色质和核信号 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 40kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HEXO
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Helicase with RNase motif, more commonly designated Dicer, cleaves double-stranded RNA (dsRNA) in the RNA interference and small temporal RNA (stRNA) pathways, producing active small RNA components (siRNAs) which target the destruction of RNA and repress gene expression. Human Dicer cleaves dsRNA independent of ATP. The 3’-5’ exonuclease ERI-1, also known as Protein 3hExo, degrades Histone mRNA after replication and may be involved in the regulation of RNA interference. ERI-1 has a high affinity for the stem-loop structure of replication-dependent Histone pre-mRNAs. It requires the 5-ACCCA-3 sequence present in stem-loop structure. ERI-1 and a stem-loop binding protein (SLBP) target opposite faces of a unique highly conserved stem-loop RNA scaffold towards the 3 end of Histone mRNA.
Function:
RNA exonuclease that binds to the 3-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2 and 3-hydroxyl groups at the last nucleotide of the histone 3-end is required for efficient degradation of RNA substrates. Also able to degrade the 3-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5-ACCCA-3 sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
Subunit:
Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3-end of histone mRNAs (By similarity). Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3-end of histone mRNAs.
Subcellular Location:
Cytoplasm. Nucleus. Nucleus, nucleolus.
Similarity:
Contains 1 exonuclease domain.
Contains 1 SAP domain.
Database links:Entrez Gene: 90459 Human
Entrez Gene: 361159 Rat
Omim: 608739 Human
SwissProt: Q8IV48 Human
SwissProt: Q5FVR4 Rat
Unigene: 20000 Human
Unigene: 17469 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.