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货号： bs-15456R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15456R-PE-Cy7
- 英文名称
- Anti-Hepatitis C Virus genotype 1a NS5 /PE-Cy7
- 中文名称
- PE-Cy7标记的丙型肝炎病毒1a基因型NS5蛋白抗体
- 别 名
- HCV 1a NS5; Hepatitis C virus NS5A; Non-structural protein 5A.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细菌及病毒
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Hepatitis C Virus genotype 1a
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 7.9kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from Hepatitis C Virus genotype 1a NS5
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
No data available.
Function:
The papain-like proteinase 1 (PL1-PRO) and papain-like proteinase 2 (PL2-PRO) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both Lys-48- and Lys-63-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3 (By similarity).
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1-phosphate (ADRP)-binding function (By similarity).
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity).
Nsp9 is a ssRNA-binding protein (By similarity).
Subunit:
3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer (By similarity).
Subcellular Location:
Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential).
Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential).
Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential).
Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.
Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.
Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.
Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Note=nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes.
Post-translational modifications:
Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).
Similarity:
Belongs to the coronaviruses polyprotein 1ab family.
Contains 1 Macro domain.
Contains 2 peptidase C16 domains.
Contains 1 peptidase C30 domain.
Database links:
UniProtKB/Swiss-Prot: P0C6U5.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.