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货号： bs-15459R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15459R-PE-Cy7
- 英文名称
- Anti-HERC1 /PE-Cy7
- 中文名称
- PE-Cy7标记的鸟苷酸释放因子p532蛋白抗体
- 别 名
- Guanine nucleotide exchange factor p532; Hect (homologous to the E6 AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1) like domain (RLD) 1; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; HECT domain and RCC1 like domain containing protein 1; p532; p619; Probable E3 ubiquitin-protein ligase HERC1; HERC1_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 532kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HERC1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
HERC1 is a stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes.
Function:
Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Subunit:
Interacts with TSC2; interaction is inhibited by TSC1. Interacts with PKM, ARF1 and ARF6. Forms a ternary complex with clathrin heavy chain (CLTC) and HSPA1A.
Subcellular Location:
Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin-rich surface protrusions.
Tissue Specificity:
Widely expressed.
Similarity:
Contains 1 B30.2/SPRY domain.
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 14 RCC1 repeats.
Contains 11 WD repeats.
Database links:Entrez Gene: 538029 Cow
Entrez Gene: 8925 Human
Entrez Gene: 235439 Mouse
Entrez Gene: 100153537 Pig
Entrez Gene: 315771 Rat
Omim: 605109 Human
SwissProt: Q15751 Human
Unigene: 210385 Human
Unigene: 244179 Mouse
Unigene: 232088 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.