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货号： bs-15462R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15462R-PE-Cy7
- 英文名称
- Anti-HERC4/PE-Cy7
- 中文名称
- PE-Cy7标记的HERC4 E3泛素蛋白连接酶抗体
- 别 名
- DKFZP564G092; HECT and RLD domain containing E3 ubiquitin protein ligase 4; HECT domain and RCC1 like domain containing protein 4; HECT domain and RCC1-like domain-containing protein 4; Hect domain and RLD 4; HERC 4; HERC4; HERC4_HUMAN; KIAA1593; Probable E3 ubiquitin protein ligase HERC4; Probable E3 ubiquitin-protein ligase HERC4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 119kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HERC4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).
Function:
Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates (By similarity).
Subcellular Location:
Cytoplasm, cytosol. Note=shows a punctate cytoplasmic distribution.
Tissue Specificity:
Expressed in brain and testis and detected in heart and placenta.[DEVELOPMENTAL STAGE] Expressed in fetal brain.
Similarity:
Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
Contains 7 RCC1 repeats.
Database links:Entrez Gene: 26091 Human
Entrez Gene: 67345 Mouse
Omim: 609248 Human
SwissProt: Q5GLZ8 Human
SwissProt: Q6PAV2 Mouse
Unigene: 51891 Human
Unigene: 234437 Mouse
Unigene: 441725 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.