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货号： bs-15423R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15423R-PE-Cy7
- 英文名称
- Anti-HCC1/PE-Cy7
- 中文名称
- PE-Cy7标记的RNA结合蛋白39抗体
- 别 名
- CAPER alpha; CAPER; CAPERalpha; CC1.3; Coactivator of activating protein 1 and estrogen receptors; Coactivator of AP1 and ERs; DKFZp781C0423; FLJ44170; HCC 1; Hepatocellular carcinoma protein 1; RBM 39; RBM39; RNA binding motif protein 39; RNA binding region (RNP1 RRM) containing 2; RNA binding region containing protein 2; RNPC2; Splicing factor CC1.3; Splicing factor CC1.4; Splicing factor HCC1; Transcription coactivator CAPER; RBM39_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 染色质和核信号 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 59kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HCC1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
HCC1 is a member of the U2AF65 family of proteins. The encoded protein is found in the nucleus, where it co-localizes with core spliceosomal proteins. It has been shown to play a role in both steroid hormone receptor-mediated transcription and alternative splicing, and it is also a transcriptional coregulator of the viral oncoprotein v-Rel. Multiple transcript variants have been observed for this gene. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Aug 2011].
Function:
Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process.
Subunit:
Interacts with NCOA6 (By similarity). Interacts with RSRC1 (via Arg/Ser-rich domain).
Subcellular Location:
Nucleus speckle. Note=Concentrated in nuclear speckles. Colocalizes with the core spliceosomal snRNP proteins.
Tissue Specificity:
Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain. Expressed at intermediate level in kidney, liver and heart.
Similarity:
Belongs to the splicing factor SR family.
Contains 3 RRM (RNA recognition motif) domains.
Database links:
UniProtKB/Swiss-Prot: Q14498.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.