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货号： bs-15425R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15425R-PE-Cy7
- 英文名称
- Anti-HCE/PE-Cy7
- 中文名称
- PE-Cy7标记的5’-三磷酸聚核苷酸抗体
- 别 名
- RNGTT; CAP1A; GTase; GTP--RNA guanylyltransferase; hCAP; HCAP1; HcE; HCE1; MCE1; MCE1_HUMAN; mRNA 5-triphosphatase; mRNA capping enzyme; mRNA guanyltransferase; mRNA guanylyltransferase; polynucleotide 5 trisphosphatase; RNA guanylyltransferase and 5 phosphatase; TPase;
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 染色质和核信号 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 69kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HCE
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
RNGTT (RNA guanylyltransferase and 5-phosphatase) is a 597 amino acid protein that localizes to the nucleus and exists as four alternatively spliced isoforms. Expressed in kidney, lung, heart, brain, liver, testis, skin and muscle, RNGTT acts as a bifunctional mRNA-capping enzyme that exhibits RNA 5-triphosphatase activity at its N-terminus and mRNA guanylyltransferase activity at its C-terminus. Via its catalytic activity, RNGTT facilitates the first two steps of mRNA cap formation, naming the removal of a γ-phosphate from the end of nascent mRNA and the subsequent transfer of the phospho residue to the 5’-diphosphate terminus. The gene encoding RNGTT maps to human chromosome 6, which contains 170 million base pairs and comprises nearly 6% of the human genome.
Function:
Bifunctional mRNA-capping enzyme exhibiting RNA 5-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5-diphosphate terminus.
Subunit:
Interacts with SUPT5H and RNMT. Interacts with HIV-1 Tat.
Subcellular Location:
Nucleus.
Tissue Specificity:
Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.
Similarity:
In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
In the C-terminal section; belongs to the eukaryotic GTase family.
Database links:Entrez Gene: 8732 Human
Entrez Gene: 24018 Mouse
GenBank: AF025654 Human
Omim: 603512 Human
SwissProt: O60942 Human
SwissProt: O55236 Mouse
Unigene: 567378 Human
Unigene: 240024 Mouse
Unigene: 464346 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.