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货号： bs-15374R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15374R-PE-Cy7
- 英文名称
- Anti-GPCR TGR7/PE-Cy7
- 中文名称
- PE-Cy7标记的G蛋白偶联受体TGR7蛋白抗体
- 别 名
- Beta-alanine receptor; G-protein coupled receptor TGR7; Mas-related G-protein coupled receptor member D; MRGD; MRGPRD; MRGRD; TGR7; MRGRD_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 36kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GPCR TGR7
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Mas-related G protein-coupled receptors are sensory neuron-specific G protein-coupled receptors that are usually involved in the development and function of nociceptive neurons and may also regulate the sensation or modulation of pain. MRGD (MAS-related GPR, member D), also known as MRGPRD or TGR7, is a 321 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor 1 family and the Mas subfamily. MRGD is suggested to function specifically as a receptor for beta-alanine, a naturally occurring beta amino acid. Beta-alanine induces Ca2+ influx and decreases forskolin-stimulated cAMP production in cells expressing MRGD. Neurons of outer epidermis that express MRGD act as nociceptors in which they respond indirectly to external stimuli by detecting ATP release in the skin. MRGD is encoded by a gene located on human chromosome 11q13.2.
Function:
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
Similarity:
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Database links:Entrez Gene: 116512Human
Entrez Gene: 211578Mouse
Entrez Gene: 293648Rat
SwissProt: Q8TDS7Human
SwissProt: Q91ZB8Mouse
SwissProt: Q7TN41Rat
Unigene: 527802Human
Unigene: 370299Mouse
Unigene: 162482Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.