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货号： bs-13558R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13558R-PE-Cy7
- 英文名称
- Anti-ZNF93/PE-Cy7
- 中文名称
- PE-Cy7标记的锌指蛋白93抗体
- 别 名
- FLJ12488; HPF34; HTF34; TF34; Zinc finger protein 505; Zinc finger protein 93 (HTF34); Zinc finger protein 93; Zinc finger protein HTF34; ZNF505; ZNF93; ZNF93_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 71kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ZBT24/ZNF45
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5 end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
DISEASE:
Expressed early during embryonic development.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 17 C2H2-type zinc fingers.
Contains 1 KRAB domain.
Database links:Entrez Gene: 81931Human
Omim: 603975Human
SwissProt: P35789Human
Unigene: 301059Human
Unigene: 723768Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.