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货号： bs-15245R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15245R-PE-Cy7
- 英文名称
- Anti-C6orf25/PE-Cy7
- 中文名称
- PE-Cy7标记的6号染色体开放阅读框25抗体
- 别 名
- Chromosome 6 open reading frame 25; G6b; G6B protein; Immunoglobulin receptor; MGC142279; MGC142281; NG31; Protein G6b;G6B_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 24kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human C6orf25
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
C6orf25 is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. It is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene.
Function:
Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide. Appears to operate in a calcium-independent manner. Isoform B is a putative inhibitory receptor. Isoform A may be its activating counterpart.
Subunit:
Interacts with PTPN6 and PTPN11. Binds to heparin.
Subcellular Location:
Isoform E: Endoplasmic reticulum. Golgi apparatus.
Isoform D: Endoplasmic reticulum. Golgi apparatus.
Isoform B: Cell membrane; Single-pass type I membrane protein.
Isoform A: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed in a restricted set of hematopoietic cell lines including the erythroleukemia cell line K-562 and the T-cell leukemia cell lines MOLT-4 and Jurkat. Not detected in the monocyte-like cell line U-937, the B-cell-like cell line Raji, the fibroblast cell lines TK and HeLa, or the natural killer cell lines NKL, NK 62 and YT. Expressed in platelets.
Post-translational modifications:
All isoforms are N-glycosylated.
Isoform E is O-glycosylated.
Database links:Entrez Gene: 80739Human
Omim: 606520Human
SwissProt: O95866Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.