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货号： bs-13537R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13537R-PE-Cy7
- 英文名称
- Anti-GPR44/PE-Cy7
- 中文名称
- PE-Cy7标记的G蛋白偶联受体44抗体
- 别 名
- GPCR GPR44; CD294; CD 294; CD294 antigen; Chemoattractant receptor homologous molecule expressed on Th2 cells; chemoattractant receptor-homologous; Chemoattractant receptor-homologous molecule expressed on Th2 cells; CRTH 2; CRTH2; DL1R; DP2 prostaglandin receptor; G Protein Coupled Receptor 44; GPR 44; Gpr44; PD2R2_HUMAN; PTGDR2; Putative G protein coupled receptor 44; Putative G-protein coupled receptor 44; GPCR 44.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 43kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GPR44/CD294
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The human chemoattractant receptor-homologous molecule (CRTH2, GPR44, G protein-coupled receptor 44) maps to chromosome 11q12-q13.3 and encodes a 472 amino acid G protein-coupled leukocyte chemoattractant receptor. Chemoattractant receptors present on Th2 cells respond to parasites and play a central role in allergic inflammation; they are absent on type 1 T helper (Th1) cells, which address intracellular bacteria and many viruses. CRTH2 contains seven putative transmembrane domains and mediates signals to the interior of the cell upon exposure to its cognate ligand prostaglandin (PG) D2, which is able to attract basophils, eosinophils, type 2 Th (Th2) cells and type 2 cytotoxic (Tc2) CD8+ T lymphocytes. CRTH2 expression on active Th2 cells influences supportive roles in Th2-type immune reactions. 3.5 kb CRTH2 transcripts are present in thalamus, frontal cortex, pons, hippocampus, hypothalamus and caudate, while 3.4 kb transcripts are present in fetal liver, leukocytes and thymus.
Function:
Orphan receptor.
Subcellular Location:
Cell membrane.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 11251Human
Omim: 604837Human
SwissProt: Q9Y5Y4Human
Unigene: 299567Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.