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货号： bs-13541R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13541R-PE-Cy7
- 英文名称
- Anti-GPR58/PE-Cy7
- 中文名称
- PE-Cy7标记的G蛋白偶联受体58抗体
- 别 名
- GPCR GPR58; G protein coupled receptor 58; phBL5; GPCR 58; GPR 58; TAAR2; Trace amine associated receptor 2; TAAR2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 转录调节因子 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 40kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GPR58
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Trace amines are endogenous molecules structurally related to classical biogenic amines that are linked to psychiatric conditions. A family of G-protein coupled receptors referred to as trace-amine-associated receptors (TAAR) are activated by trace amines and are present in very low levels in mammalian tissue. TAAR’s contain several structural features that are similar to the rhodopsin beta-adrenergic receptor superfamily, including the positions of the seven transmembrane regions that provide common ligand-binding pockets as well as the short N- and C-terminal domains. TAAR proteins are potential targets for drugs of abuse, such as amphetamine and MDMA, as well as neuropsychiatric disorders including schizophrenia, depression, and attention deficit disorder. TAAR-1 is a 340 amino acid protein that increases intracellular cAMP accumulation in response to beta-phenylethylamine and tyramine. TAAR-1 is associated with the detection of social cues, illustrating its significance as a therapeutic target.
Function:
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. GPCR GPR58 is a member of this family (subfamily Orphan-A). GPR58 expression has not been reported from human liver and several brain areas.
Subcellular Location:
Integral membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 9287 Human
Omim: 604849 Human
SwissProt: Q9P1P5 Human
Unigene: 272382 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.