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货号： bs-13514R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13514R-PE-Cy7
- 英文名称
- Anti-GPR12/PE-Cy7
- 中文名称
- PE-Cy7标记的G蛋白偶联受体12抗体
- 别 名
- FLJ18149; FLJ97704; G protein coupled receptor 12; G-protein coupled receptor 12; GPCR12; GPCR21; GPR 12; GPR12; GPR12_HUMAN; MGC138349; MGC138351; Probable G protein coupled receptor GPR12; GPCR GPR12.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 37kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human G protein coupled receptor 12
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR12 is a 334 amino acid peptide that is expressed primarily in brain, particularly in regions where neuronal differentiation takes place. GPR12 is coupled to an inhibitory G protein. It positively influences differentiation and maturation of post-mitotic neurons, and it may promote the growth of neuronal precursor cells.
Function:
Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.
Subcellular Location:
Cell membrane.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 2835 Human
Entrez Gene: 14738 Mouse
Entrez Gene: 80840 Rat
Omim: 600752 Human
SwissProt: P47775 Human
SwissProt: P35412 Mouse
SwissProt: P30951 Rat
Unigene: 123034 Human
Unigene: 153539 Mouse
Unigene: 88417 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.