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货号： bs-13503R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13503R-PE-Cy7
- 英文名称
- Anti-GPBP1/PE-Cy7
- 中文名称
- PE-Cy7标记的富含GC启动子结合蛋白1/血管壁相连蛋白抗体
- 别 名
- Vasculin; DKFZp761C169; GC rich promoter binding protein 1; GC-rich promoter-binding protein 1; GPBP; Gpbp1; GPBP1_HUMAN; MGC126339; SSH6; Vascular wall linked; Vascular wall-linked protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GPBP1/Vasculin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Vascular wall-linked protein, or Vasculin, is primarily expressed in the arterial wall and in plasma. It is also differentially expressed in human atherogenesis. Alternative splicing of exon 3 of the Vasculin gene produces three variants. Vasculin binds to and activates the minimal self-sufficient promoter element (MSPE) of the mouse Ada gene promoter and binds to and partially suppresses the GC-rich promoter of the nonhomologous human TOP2A gene promoter. It acts as a nuclear factor that can form complexes with TATA-binding proteins, transcription factors TFIIB and TFIIF, RNA polymerase II and p300. The regulated expression of Vasculin in plaques suggests that it may be involved in atherogenesis, and its presence in plasma may implicate Vasculin as a marker for atherosclerosis.
Function:
Functions as a GC-rich promoter-specific transactivating transcription factor.
Subunit:
Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP (By similarity).
Subcellular Location:
Nucleus. Cytoplasm. According to PubMed:12842993, it localizes to the cytoplasm.
Tissue Specificity:
Widely expressed. Some isoforms may be specifically expressed in veins and arteries (at protein level). Isoform 4 is widely expressed. Isoform 1, isoform 2 and isoform 3 may be specifically expressed in vascular smooth muscle cells.
Similarity:
Belongs to the vasculin family.
Database links:Entrez Gene: 65056 Human
Entrez Gene: 73274 Mouse
Entrez Gene: 294734 Rat
Entrez Gene: 613751 Cow
SwissProt: Q0P5K1 Cow
SwissProt: Q86WP2 Human
SwissProt: Q9H0D4 Human
SwissProt: Q9H785 Human
SwissProt: Q3TQR2 Mouse
SwissProt: Q6NXH3 Mouse
SwissProt: Q6TYE7 Mouse
SwissProt: Q8R252 Mouse
Unigene: 17440 Cow
Unigene: 444279 Human
Unigene: 441830 Mouse
Unigene: 57286 Mouse
Unigene: 33325 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.