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货号： bs-8873R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8873R-PE-Cy7
- 英文名称
- Anti-CD36/PE-Cy7
- 中文名称
- PE-Cy7标记的CD36抗体
- 别 名
- Platelet glycoprotein IV; GPIV; lycoprotein IIIb; GPIIIB; Leukocyte differentiation antigen CD36; PAS IV; Platelet collagen receptor; Fatty acid translocase; FAT; Thrombospondin receptor; CD36_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 干细胞 细胞表面分子 细胞类型标志物 血管内皮细胞 内皮细胞 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CD36/PAS-4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
CD36 is a membrane glycoprotein on platelets, monocytes and umbilical vein endothelial cells. CD36 binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. CD36 plays a key role in both phagocytosis and lipid recycling, for constant production of mature spermatozoa. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. Thrombospondins are widely distributed proteins that influence a variety of adhesive processes and CD36 may have important functions as a cell adhesion molecule.
Function:
Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects.
Subunit:
Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Post-translational modifications:
N-glycosylated and O-glycosylated with a ratio of 2:1.
DISEASE:
Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].
Similarity:
Belongs to the CD36 family.
Database links:Entrez Gene: 948Human
Entrez Gene: 12491Mouse
Entrez Gene: 29184Rat
Omim: 173510Human
SwissProt: P16671Human
SwissProt: Q08857Mouse
SwissProt: Q07969Rat
Unigene: 120949Human
Unigene: 18628Mouse
Unigene: 406799Mouse
Unigene: 102418Rat
Unigene: 205840Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD36属一种多功能细胞膜受体，CD36参与长链脂肪酸的吸附和调节细胞凋亡残物的清理和巨噬细胞的吞噬作用， 属于一种抗蛋白酶血小板膜表面糖蛋白。
CD36 广泛在单核细胞、巨噬细胞、内皮层细胞、血小板、红细胞前板、脂肪细胞、肌肉细胞以及乳腺内皮层细胞中有不同的表达。CD36抗原是血小板反应素的配体，两者结合后产生抑制肿瘤血管生成的效应。