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货号： bs-13372R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13372R-PE-Cy7
- 英文名称
- Anti-GLEPP1/PE-Cy7
- 中文名称
- PE-Cy7标记的肾小球上皮蛋白1抗体
- 别 名
- FMI; GLEPP 1; Glomerular epithelial protein 1; hPTP-J; Pancreatic carcinoma phosphatase 2; PCP-2; PCP2; Phosphotyrosine phosphatase U2; Protein tyrosine phosphatase PTP U2; Protein tyrosine phosphatase PTPU2; Protein tyrosine phosphatase receptor type O; Protein tyrosine phosphatase U2; Protein-tyrosine phosphatase J; Protein-tyrosine phosphatase pi; Protein-tyrosine phosphatase receptor omicron; PTP pi; PTP U2; PTP-J; PTP-RO; PTP-U2; PTPase U2; PTPRO; PTPRO_HUMAN; PTPROt; PTPU 2; PTPU2; R-PTP-O; R-PTP-psi; Receptor type protein tyrosine phosphatase O; Receptor type tyrosine protein phosphatase O; Receptor-type protein-tyrosine phosphatase psi; Receptor-type tyrosine-protein phosphatase O; Receptor-type tyrosine-protein phosphatase U.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 135kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GLEPP1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Protein phosphatases play critical roles in the regulation of signal transduction pathways. The family can be separated into three general categories, which are distinguished on the basis of substrate specificity. The first and largest category, termed protein tyrosine phosphatases or PTPs, includes transmembrane proteins, membrane associated proteins and proteins that localize to nuclei. The second category of protein phosphatases dephosphorylate proteins on phosphoserine and phosphothreonine residues, whereas the third category of protein phosphatases exhibit dual specificities and can dephosphorylate proteins on phosphotyrosine and phosphoserine/phosphothreonine residues. Glomerular epithelial protein 1 (GLEPP1), also designated protein tyrosine phosphatase U2 (PTPase U2) or receptor-type tyrosine-protein phosphatase O (PTPRO), belongs to the protein-tyrosine phosphatase family. GLEPP1 is a Type I membrane protein containing 8 fibronectin type-III domains and 1 tyrosine-protein phosphatase domain. GLEPP1 is expressed primarily in the glomeruli of the kidney, but is also detected in placenta, lung and brain.
Function:
Possesses tyrosine phosphatase activity.
Subcellular Location:
Membrane.
Tissue Specificity:
Glomerulus of kidney. Also detected in brain, lung and placenta.
DISEASE:
Defects in PTPRO are the cause of nephrotic syndrome type 6 (NPHS6) [MIM:614196]. NPHS6 is a renal disease characterized clinically by proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.
Contains 8 fibronectin type-III domains.
Contains 1 tyrosine-protein phosphatase domain.
Database links:Entrez Gene: 5800 Human
Omim: 600579 Human
SwissProt: Q16827 Human
Unigene: 160871 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.