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货号： bs-13262R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13262R-PE-Cy7
- 英文名称
- Anti-GABPB2/PE-Cy7
- 中文名称
- PE-Cy7标记的GA结合蛋白转录因子β/GABP-β1/GABP-β2抗体
- 别 名
- MGC29891; BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B; GA binding protein transcription factor beta subunit 1 transcript variant gamma 2; GA binding protein transcription factor, beta subunit 1; GA binding protein transcription factor, beta subunit 2; GA-binding protein subunit beta-1; GABP subunit beta-1; GABP subunit beta-2; GABP1_HUMAN; GABPB; GABPB-1; GABPB-2; GABPB1; GABPB2; NRF2B1; NRF2B2; Nuclear respiratory factor 2; Transcription factor E4TF1-47; Transcription factor E4TF1-53.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 42kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GABPB2/GABPB1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The transcription factor GA-binding protein (GABP) is composed of two subunits, the Ets-related GABP-alpha and a GABP-alpha-associated subunit, GABP beta. GABP alpha binds to a specific DNA sequence and GABP beta exists as b1 and b2 splice variants that differ in their C-termini. In primary neuronal cultures, GABP beta is expressed in both the cytoplasm and the nucleus, whereas GABP alpha is expressed mainly in the nucleus. GABP is constitutively expressed as either a GABP alpha beta heterodimer or a GABP alpha b heterotetramer, both of which can modify GABP-dependent transcription in vitro and in vivo . The GABP alpha beta tetrameric complex performs many different functions, such as stimulating transcription of the adenovirus E4 gene, differentially activating BRCA1 expression in human breast cell lines, potentiating Tat-mediated activation of long terminal repeat promoter transcription and viral replication in certain cell types, acting as a coordinator of mitochrondrial and nuclear transcription for cytochrome oxidase in neurons and assisting in the regulation of rpL32 gene transcription.
Function:
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.
Subunit:
Heterotetramer of two alpha and two beta subunits. Interacts with HCFC1, causing repression of transcriptional activity.
Subcellular Location:
Nucleus.
Similarity:
Contains 5 ANK repeats.
Database links:Entrez Gene: 2553 Human
Entrez Gene: 14391 Mouse
Entrez Gene: 364738 Rat
Omim: 600610 Human
SwissProt: Q06547 Human
SwissProt: Q00420 Mouse
Unigene: 654350 Human
Unigene: 293266 Mouse
Unigene: 61149 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.