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货号： bs-13263R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13263R-PE-Cy7
- 英文名称
- Anti-GAD65 + GAD67/PE-Cy7
- 中文名称
- PE-Cy7标记的谷氨酸脱羧酶65+谷氨酸脱羧酶67抗体
- 别 名
- 65 kDa glutamic acid decarboxylase; DCE 2; DCE2; GAD 2; GAD 65; GAD-2; GAD-65;GAD 65, GAD2; Glutamate Decarboxylase 2 (pancreatic islets and brain 65kDa); Glutamate Decarboxylase 2; Glutamate Decarboxylase 65; Glutamate decarboxylase 65 kDa isoform; Glutamic Acid Decarboxylase 2; Glutamic Acid Decarboxylase 65; DCE1_HUMAN; DCE2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 细胞类型标志物
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 65+67kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GAD65 + GAD67
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma aminobutyric acid from L glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin dependent diabetes. This gene may also play a role in the stiff man syndrome.
Function:
Catalyzes the production of GABA.
Subcellular Location:
Cytoplasm; cytosol. Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
Similarity:
Belongs to the group II decarboxylase family.
Database links:Entrez Gene: 2572 Human
Entrez Gene: 14417 Mouse
Entrez Gene: 24380 Rat
Omim: 138275 Human
SwissProt: Q05329 Human
SwissProt: Q5VZ29 Human
SwissProt: Q5VZ30 Human
SwissProt: P48320 Mouse
SwissProt: Q548L4 Mouse
SwissProt: Q05683 Rat
Unigene: 231829 Human
Unigene: 4784 Mouse
Unigene: 29951 Rat
Entrez Gene: 2571 Human
Entrez Gene: 14415 Mouse
Entrez Gene: 24379 Rat
Omim: 605363 Human
SwissProt: Q99259 Human
SwissProt: P48318 Mouse
SwissProt: P18088 Rat
Unigene: 420036 Human
Unigene: 272120 Mouse
Unigene: 91245 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.