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货号： bs-13252R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13252R-PE-Cy7
- 英文名称
- Anti-G3BP2/PE-Cy7
- 中文名称
- PE-Cy7标记的G3BP2蛋白抗体
- 别 名
- G3BP 2; G3BP-2; G3BP2; G3BP2_HUMAN; GAP SH3 domain binding protein 2; GAP SH3 domain-binding protein 2; GTPase activating protein (SH3 domain) binding protein 2; Ras GTPase activating protein SH3 domain binding protein 2; Ras GTPase-activating protein-binding protein 2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 54kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human G3BP2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
G3BP2 (GTPase activating protein (SH3 domain) binding protein 2) is a 482 amino acid protein that localizes to the cytoplasm and contains one NTF2 domain and one RRM domain. Existing as two alternatively spliced isoforms, G3BP2 acts as a scaffold protein that is thought to be involved in mRNA transport and is subject to post-translational methylation on select arginine residues. The gene encoding G3BP2 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntingtons disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Function:
Probable scaffold protein that may be involved in mRNA transport.
Subunit:
Binds to the N-terminal domain of I-kappa-B-alpha.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Arg-457 and Arg-468 are dimethylated, probably to asymmetric dimethylarginine.
Similarity:
Contains 1 NTF2 domain.
Contains 1 RRM (RNA recognition motif) domain.
Database links:Entrez Gene: 9908 Human
Entrez Gene: 23881 Mouse
Entrez Gene: 305240 Rat
SwissProt: Q9UN86 Human
SwissProt: P97379 Mouse
SwissProt: Q5R9L3 Orangutan
Unigene: 303676 Human
Unigene: 290530 Mouse
Unigene: 473827 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.