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货号： bs-10265R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-10265R-PE-Cy7
- 英文名称
- Anti-SFTPA1/PE-Cy7
- 中文名称
- PE-Cy7标记的肺表面活性蛋白A抗体
- 别 名
- SP-A；Surfactant Protein A; pulmonary surfactant-associated glycoprotein A; Pulmonary surfactant-associated protein A2 precursor; SP-A2; PSP-A; PSPA; Alveolar proteinosis protein; 35 kDa pulmonary surfactant-associated protein; COLEC4; MGC133365; Pulmonary surfactant apoprotein; Pulmonary surfactant associated protein; SFTP1; SFTPA; SFTPA1; SFTPA1B; SP A; SP A1; Surfactant pulmonary associated protein A1; SFTPA_MOUSE; Collectin-5; Sftp-1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat, Guinea Pig,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 25kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse SFTPA
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009].
Function:
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
Subunit:
Oligomeric complex of 6 set of homotrimers.
Subcellular Location:
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
DISEASE:
Defects in SFTPA2 are a cause of pulmonary fibrosis idiopathic (IPF) [MIM:178500]. Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease.
Similarity:
Belongs to the SFTPA family.
Contains 1 C-type lectin domain.
Contains 1 collagen-like domain.
Database links:Entrez Gene: 610540 Dog
Entrez Gene: 653509 Human
Entrez Gene: 20387Mouse
Omim: 178630 Human
SwissProt: P06908 Dog
SwissProt: Q8IWL2 Human
Unigene: 535295 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.