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货号： bs-13200R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13200R-PE-Cy7
- 英文名称
- Anti-FOXE3/PE-Cy7
- 中文名称
- PE-Cy7标记的叉头蛋白E3抗体
- 别 名
- Drosphilia Forkhead Homolog Like 12; Drosphilia Forkhead Homolog Like 12; FKHL 12; FKHL 12; FKHL12; Forkhead Box E3; Forkhead Box E3; Forkhead Related Activator 8; Forkhead Related Activator 8; Forkhead related protein FKHL12; FOXE3 forkhead box E3; FREAC 8; FREAC 8; FREAC8; FOXE3_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 33kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FOXE3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009].
Function:
FOXE3 is a forkhead transcription factor. These factors are distinguished by a characteristic 100-amino acid motif that was originally identified in Drosophila; a common function of forkhead transcription factors is their involvement in early developmental decisions of cell fates during embryogenesis. Defects in FOXE3 are a cause of several ocular disorders. FOXE3 may be essential for the early normal developmental of the lens. FOXE3 had been shown to play a crucial role in vertebrate lens formation and is one of the earliest integrators of several signaling pathways that cooperate to form a lens.
Subcellular Location:
Nuclear.
DISEASE:
Defects in FOXE3 are a cause of anterior segment mesenchymal dysgenesis (ASMD) [MIM:107250]; also known as anterior segment ocular dysgenesis (ASOD). ASMD consists of a range of developmental defects in structures at the front of the eye, resulting from abnormal migration or differentiation of the neural crest derived mesenchymal cells that give rise to the cornea, iris, and other components of the anterior chamber during eye development. Mature anterior segment anomalies are associated with an increased risk of glaucoma and corneal opacity. Conditions falling within the phenotypic spectrum include aniridia, posterior embryotoxon, Axenfeld anomaly, Reiger anomaly/syndrome, Peters anomaly, and iridogoniodysgenesis.
Defects in FOXE3 are a cause of congenital primary aphakia (CPA) [MIM:610256]. Aphakia is a rare congenital eye disorder in which the lens is missing. It has been histologically subdivided into primary and secondary forms, in accordance with the severity of defects of the ocular tissues, whose development requires the initial presence of a lens. CPA results from an early developmental arrest, around the 4th-5th week of gestation in humans, that prevents the formation of any lens structure and leads to severe secondary ocular defects, including a complete aplasia of the anterior segment of the eye. In contrast, in secondary aphakic eyes, lens induction has occurred, and the lens vesicle has developed to some degree but finally has progressively resorbed perinatally, leading, therefore, to less-severe ocular defects.
Similarity:
Contains 1 fork-head DNA-binding domain.
Database links:
UniProtKB/Swiss-Prot: Q13461.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.