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货号: bs-13145R-PE-Cy7 基本售价: 2980.0 元 规格: 100ul
产品信息
- 产品编号
- bs-13145R-PE-Cy7
- 英文名称
- Anti-FARSLA/CML33/PE-Cy7
- 中文名称
- PE-Cy7标记的慢性粒细胞白血病33抗体
- 别 名
- CML 33; CML33; FARS; FARSA; FARSL; FRSA; PheHA; Phenylalanine tRNA ligase 1 alpha cytoplasmic; Phenylalanine tRNA ligase alpha chain; Phenylalanine tRNA synthetase alpha subunit; Phenylalanine tRNA synthetase like alpha subunit; Phenylalanyl tRNA synthetase alpha chain; Phenylalanyl tRNA synthetase alpha subunit; Phenylalanyl tRNA synthetase like alpha subunit; PheRS.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FARSLA/CML33
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Aminoacyl-tRNA synthetases consist of a family of enzymes that catalyze the specific aminoacylation of tRNA by their cognate amino acid in the initial step of ribosome-dependent protein biosynthesis. FARSLA, also known as FRSA, CML33, FARSL or PheHA (phenylalanyl-tRNA synthetase, alpha subunit), is a member of the class-II aminoacyl-tRNA synthetase family and is highly expressed in proliferating cells of bone marrow. FARSLA is a cytoplasmic phenylalanine-tRNA synthetase that functions as a heterodimer consisting of a catalytic alpha-subunit and a regulatory beta-subunit. The alpha-subunit is responsible for forming the amino acid binding pocket, mediating the ATP/aminoacyl adenylate binding, and interacts with the acceptor stem of the tRNA. FARSLA functions in a cell cycle-dependent and differentiation-dependent manner.
Function:
FARSLA (Phenylalanyl-tRNA synthetase alpha chain) is an aminoacyl-tRNA synthetase. These are a class of enzymes that charge tRNAs with their cognate amino acids. Cytoplasmic phenylalanine-tRNA synthetase is a heterodimer consisting of a catalytic alpha subunit, FARSLA, and a regulatory beta subunit, FARSLB. This protein has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase family shown to exhibit this type of regulated expression.
Subcellular Location:
Cytoplasmic.
Similarity:
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
Database links:Entrez Gene: 2193 Human
Entrez Gene: 66590 Mouse
Entrez Gene: 288917 Rat
Omim: 602918 Human
SwissProt: Q9Y285 Human
SwissProt: Q8C0C7 Mouse
SwissProt: Q505J8 Rat
Unigene: 23111 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.