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货号： bs-13022R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13022R-PE-Cy7
- 英文名称
- Anti-DNA Polymerase theta/POLH/PE-Cy7
- 中文名称
- PE-Cy7标记的DNA聚合酶θ/DNA pol θ抗体
- 别 名
- DKFZp781A0112; DNA polymerase eta; DNA polymerase theta; DPOLQ_HUMAN; POLH; POLQ; Polymerase (DNA directed) theta; PRO0327.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 290kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DNA Polymerase theta/POLH
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 亱C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20亱C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 亱C.
- 产品介绍
- background:
DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases (1). In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches (2). These exonucleases include the family of DNA polymerases (3). DNA pol alpha, beta, gamma, and e are involved in DNA replication and repair (4). DNA pol gammaand DNA pol e are multisubunit enzymes, with DNA pol 佪 consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50 (5). The nuclear-encoded DNA pol delta is the only DNA polymerase required for the replication of the mitochondrial DNA (6).
Function:
Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.
Tissue Specificity:
Highly expressed in testis.
Similarity:
Belongs to the DNA polymerase type-A family.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
Database links:Entrez Gene: 10721Human
Entrez Gene: 77782Mouse
Omim: 604419Human
SwissProt: O75417Human
Unigene: 241517Human
Unigene: 259114Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.