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货号： bs-13025R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13025R-PE-Cy7
- 英文名称
- Anti-Dnmt2/PE-Cy7
- 中文名称
- PE-Cy7标记的DNA甲基转移酶2抗体
- 别 名
- dDNMT; DmMT 2; DmMT2; DNA (cytosine 5 ) methyltransferase 2; DNA (cytosine 5) methyltransferase like protein 2; DNA (cytosine-5)-methyltransferase-like protein 2; DNA 5 cytosine methyltransferase; DNA methyltransferase 2; DNA methyltransferase homolog HsaIIP; DNA MTase homolog HsaIIP; Dnmt 2; Dnmt2; M.HsaIIP; MHsaIIP; nmt 2; nmt2; OTTHUMP00000045198; PuMet; RNMT 1; RNMT1; TRDMT 1; TRDMT_HUMAN; TRDMT1; tRNA (cytosine 5 ) methyltransferase; tRNA (cytosine(38)-C(5))-methyltransferase; tRNA aspartic acid methyltransferase 1; tRNA aspartic acid methyltransferase 1 variant 1; tRNA aspartic acid methyltransferase 1 variant 2; tRNA aspartic acid methyltransferase 1 variant 3; tRNA aspartic acid methyltransferase 1 variant 4; tRNA aspartic acid methyltransferase 1 variant 5; tRNA aspartic acid methyltransferase 1 variant 8.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 45kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Dnmt2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Methylation at the 5-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.
Function:
Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes.
Similarity:
Belongs to the C5-methyltransferase family.
Database links:
UniProtKB/Swiss-Prot: O14717.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.