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货号： bs-15076R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15076R-PE-Cy7
- 英文名称
- Anti-C1orf77/PE-Cy7
- 中文名称
- PE-Cy7标记的1号染色体开放阅读框77抗体
- 别 名
- Chromatin target of PRMT1 protein; Chromosome 1 open reading frame 77; CHTOP; CHTOP_HUMAN; DKFZp547E1010; FOP; Friend of PRMT1 protein; MGC131924; MGC86949; OTTHUMP00000035122; OTTHUMP00000035123; Pp7704; RP1 178F15.2; Small arginine- and glycine-rich protein; Small protein rich in arginine and glycine; SRAG.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 26kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human C1orf77
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
C1orf77, also known as Friend of PRMT1 protein, is a 248 amino acid protein that plays an essential role in the ligand-dependent activation of estrogen receptor target genes. C1orf77 is tightly associated with chromatin and is modified by both asymmetric and symmetric arginine methylation. Depletion of C1orf77 results in almost complete block of estradiol-induced promter occupancy by the estrogen receptor. Also, complete knockdown of C1orf77 mRNA in adult erythroid progenitors stongly induces fetal hemoglobin, suggesting that C1orf77 is a critical modulator of γ-globin gene expression. There are two isoforms of C1orf77 that are produced as a result of alternative splicing events. The gene encoding C1orf77 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1.
Function:
Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Subunit:
Interacts with PRMT1 and PRMT5. Interacts with the 5FMC complex; the interaction is methylation-dependent. Interacts with FYTTD1, SET and PRC1 complex members CBX4, RNF2 and PHC2; the interactions are methylation-independent. Interacts with ZNF148 (By similarity).
Subcellular Location:
Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm (By similarity). Note=Mostly associated with facultative heterochromatin (By similarity).
Tissue Specificity:
Expressed in an erythroid progenitor cell line derived from peripheral blood.
Post-translational modifications:
Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5 (By similarity).
Database links:Entrez Gene: 426357 Chicken
Entrez Gene: 738288 Chimpanzee
Entrez Gene: 616638 Cow
Entrez Gene: 480140 Dog
Entrez Gene: 101142690 Gorilla
Entrez Gene: 26097 Human
Entrez Gene: 66511 Mouse
Entrez Gene: 100153064 Pig
Entrez Gene: 361990 Rat
Entrez Gene: 715501 Rhesus monkey
Omim: 614206 Human
SwissProt: Q3SYW9 Cow
SwissProt: Q9Y3Y2 Human
SwissProt: Q9CY57 Mouse
SwissProt: Q498T2 Rat
Unigene: 611057 Human
Unigene: 154136 Mouse
Unigene: 15859 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.