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货号： bs-15968R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-15968R-PE-Cy7
- 英文名称
- Anti-phospho-alpha Adducin(Ser436)/PE-Cy7
- 中文名称
- PE-Cy7标记的磷酸化内收蛋白a1抗体
- 别 名
- alpha Adducin(phospho S436); alpha Adducin(phospho Ser436); p-alpha Adducin(S436); p-alpha Adducin(Ser436); ADD 1; ADD A; ADD1; ADD1 protein; ADDA; ADDA_HUMAN; Adducin 1 (alpha); Adducin 1 alpha; Alpha adducin; Alpha-adducin; Erythrocyte adducin alpha subunit; Erythrocyte hosphor subunit alpha; Erythrocyte adducin subunit alpha.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 细胞生物 信号转导 激酶和磷酸酶 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 81kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthesised phosphopeptide derived from human alpha Adducin around the phosphorylation site of Ser436
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Adducins are a family of cytoskeleton proteins encoded by three genes (Alpha, Beta, Gamma). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin Alpha is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin Alpha and Adducin Gamma is ubiquitous in contrast to the restricted expression of Adducin Beta. Adducin Beta is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.
Function:
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
Subunit:
Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit.
Subcellular Location:
Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue Specificity:
Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
Similarity:
Belongs to the aldolase class II family. Adducin subfamily.
Database links:Entrez Gene: 118 Human
Entrez Gene: 11518 Mouse
Entrez Gene: 24170 Rat
Omim: 102680 Human
SwissProt: P35611 Human
SwissProt: Q9QYC0 Mouse
SwissProt: Q63028 Rat
Unigene: 183706 Human
Unigene: 289106 Mouse
Unigene: 5788 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.