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货号： bs-12502R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12502R-PE-Cy7
- 英文名称
- Anti-Apolipoprotein O/PE-Cy7
- 中文名称
- PE-Cy7标记的载脂蛋白O抗体
- 别 名
- ApoO; 0610008C08Rik; 1110019O03Rik; Apolipoprotein O; APOO; APOO_HUMAN; FAM121B; Family with sequence similarity 121B; MGC130105; MGC130106; MGC4825; My025; MYO25; OTTHUMP00000023073; Protein FAM121B; RP23-272D10.2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 细胞生物 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 20kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ApoO/Apolipoprotein O
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Apolipoproteins are a family of fatty-acid binding proteins that transport fat through the bloodstream in the form of lipoproteins. ApoO (Apolipoprotein O), also known as FAM121B or My025, is a 198 amino acid single-pass membrane protein that belongs to the apolipoprotein family. Expressed ubiquitously with particularly high expression in diabetic heart tissue, apoO functions to promote the transport of cholesterol from macrophage cells and may be involved in regulatory mechanisms that protect lipid accumulation within the heart. ApoO is present in high density lipoproteins (HDLs) and low density lipoproteins (LDLs) and is secreted by an MTP (microsomal triglyceride transfer protein)-dependent mechanism. Two isoforms of apoO exist due to alternative splicing events.
Function:
Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.
Subcellular Location:
Membrane. Secreted.
Tissue Specificity:
Expressed in all tissues examined. Up-regulated in diabetic heart.
Post-translational modifications:
O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.
Similarity:
Belongs to the apolipoprotein O family.
Database links:Entrez Gene: 79135Human
Entrez Gene: 68316Mouse
Omim: 300753Human
SwissProt: Q9BUR5Human
SwissProt: Q9DCZ4Mouse
Unigene: 495851Human
Unigene: 343319Mouse
Unigene: 379156Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.