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货号： bs-12479R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12479R-PE-Cy7
- 英文名称
- Anti-TMEM16C/PE-Cy7
- 中文名称
- PE-Cy7标记的跨膜蛋白16C抗体
- 别 名
- Anoctamin 3; ANO3; C11orf25; GENX 3947; TMEM16C; Transmembrane protein 16C (eight membrane spanning domains); Transmembrane protein 16C; ANO3_HUMAN; DYT23; DYT24; GENX-3947.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 新陈代谢 跨膜蛋白 细胞膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 115kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TMEM16C/Anoctamin 3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
TMEM16C is a 981 amino acid multi-pass membrane protein that is encoded by a gene which maps to chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.
Function:
Anoctamin 3 belongs to the anoctamin family. Anoctamin 3 may act as a calcium activated chloride channel.
Subcellular Location:
Membrane; Multi pass membrane protein.
Similarity:
Belongs to the anoctamin family.
Database links:Entrez Gene: 63982 Human
Entrez Gene: 228432 Mouse
Entrez Gene: 100519534 Pig
Entrez Gene: 311287 Rat
Omim: 610110 Human
SwissProt: Q9BYT9 Human
SwissProt: A2AHL1 Mouse
SwissProt: F1SFZ6 Pig
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.