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货号： bs-4972R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4972R-PE-Cy7
- 英文名称
- Anti-PCK1/PE-Cy7
- 中文名称
- PE-Cy7标记的磷酸烯醇丙酮酸羧激酶抗体
- 别 名
- PCK1; PEPC; GTP; MGC22652; PEP carboxykinase; PEPCK 1; PEPCK1; PEPCKC; Phosphoenolpyruvate carboxykinase 1; Phosphoenolpyruvate carboxylase; Phosphopyruvate carboxylase.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 神经生物学 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 69kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PCK1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
PCK1 is a main control point for the regulation of gluconeogenesis. This cytosolic enzyme, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of the corresponding gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. A mitochondrial isozyme has also been characterized.
Function:
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Subunit:
Monomer.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Major sites of expression are liver, kidney and adipocytes.
Post-translational modifications:
Acetylation is increased on addition of glucose and appears to regulate the protein stability.
DISEASE:
Defects in PCK1 are the cause of cytosolic phosphoenolpyruvate carboxykinase deficiency (C-PEPCKD) [MIM:261680]. A metabolic disorder resulting from impaired gluconeogenesis. It is a rare disease with less than 10 cases reported in the literature. Clinical characteristics include hypotonia, hepatomegaly, failure to thrive, lactic acidosis and hypoglycemia. Autoposy reveals fatty infiltration of both the liver and kidneys. The disorder is transmitted as an autosomal recessive trait.
Similarity:
Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
Database links:Entrez Gene: 396458 Chicken
Entrez Gene: 282855 Cow
Entrez Gene: 403560 Dog
Entrez Gene: 5105 Human
Entrez Gene: 18534 Mouse
Entrez Gene: 100144531 Pig
Entrez Gene: 362282 Rat
Omim: 614168 Human
SwissProt: P05153 Chicken
SwissProt: P35558 Human
SwissProt: Q9Z2V4 Mouse
SwissProt: P07379 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.