产品中心
当前位置：首页>产品中心Anti-SNX6/PE-Cy7
货号： bs-12410R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12410R-PE-Cy7
- 英文名称
- Anti-SNX6/PE-Cy7
- 中文名称
- PE-Cy7标记的分选连接蛋白6抗体
- 别 名
- Sorting Nexin 6; TFAF2; TRAF4 Associated Factor 2; SNX6_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 干细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 47kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SNX6
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Two related proteins, TRAF1 and TRAF2 (TNF receptor-associated factors 1 and 2, respectively), form a heterodimeric complex that associates with the cytoplasmic domain of the tumor necrosis factor (TNF) receptor type 2 (1). A third member of this family, TRAF3 (also designated CD40bp or CRAF1) associates with the cytoplasmic domain of CD40 (2). Additional membersof the TRAF/CRAF family of signaling intermediates include TRAF4 (also designated CART1), TRAF5 and TRAF6 (3-5). TRAF4 associated factor 2 (TRAF4-AF2), also designated sorting nexin 6 (SNX6), is a member of the sorting nexin family of molecules, which are widely expressed and associate with various receptor (6).
Function:
Snx6 is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms.
Subunit:
Interacts with CDKN1B (By similarity). Interacts with TGFB receptors. Interacts with dynactin subunit DCTN1. Interacts with SNX1 and SNX2. Interacts with BACE1 and BRMS1.
Subcellular Location:
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Nucleus. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes. Only a minor proportion is seen in the nucleus.
Similarity:
Belongs to the sorting nexin family.
Contains 1 PX (phox homology) domain.
Database links:Entrez Gene: 423319 Chicken
Entrez Gene: 58533 Human
EntrezGene: 72183 Mouse
Omim: 606098 Human
SwissProt: Q9BUY3 Human
SwissProt: Q9UNH7 Human
SwissProt: Q6P8X1 Mouse
SwissProt: Q8R0Z4 Mouse
SwissProt: Q9CZ03 Mouse
Unigene: 583855 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.