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货号： bs-12337R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12337R-PE-Cy7
- 英文名称
- Anti-MAEA/PE-Cy7
- 中文名称
- PE-Cy7标记的细胞增殖诱导蛋白5/肺癌相关蛋白10抗体
- 别 名
- 1110030D19Rik; Cell proliferation inducing gene 5 protein; Cell proliferation-inducing gene 5 protein; EMP; Erythroblast macrophage protein; HLC 10; HLC-10; HLC10; Human lung cancer oncogene 10 protein; Lung cancer related protein 10; lung cancer-related protein 10; Macrophage erythroblast attacher; MAEA; MAEA_HUMAN; MGC93683; PIG5; proliferation-inducing gene 5.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 发育生物学 干细胞 细胞凋亡 细胞粘附分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 45kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MAEA
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Emp is a 396 amino acid ubiquitously expressed adhesion protein. Expressed as 5 alternatively spliced isoforms, Emp contains one CTLH domain and one LisH domain. Emp can form a complex with F-actin, which is involved regulating actin distribution in erythroblasts and macrophages. Considered to assist with cell division and nuclear architecture, Emp is localized with condensed chromatin at prophase, nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis. Although the exact function of Emp is unknown, Emp is suggested to be involvement in erythroblast-macrophage cell attachment, terminal maturation and enucleation of erythroid cells, and inhibiting apoptosis of erythroblasts.
Function:
Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA-mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.
Subunit:
Forms a complex with F-actin.
Subcellular Location:
Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled-like pattern.
Tissue Specificity:
Ubiquitous.
Similarity:
Contains 1 CTLH domain.
Contains 1 LisH domain.
Database links:Entrez Gene: 10296Human
Entrez Gene: 59003Mouse
Entrez Gene: 298982Rat
Entrez Gene: 426024Chicken
Entrez Gene: 511956Cow
Omim: 606801Huma
SwissProt: Q5F398Chicken
SwissProt: Q3MHJ2Cow
SwissProt: Q7L5Y9Human
SwissProt: Q4VC33Mouse
SwissProt: Q5RKJ1Rat
Unigene: 139896Human
Unigene: 281642Mouse
Unigene: 101181Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.