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货号： bs-12317R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12317R-PE-Cy7
- 英文名称
- Anti-SCUBE3/PE-Cy7
- 中文名称
- PE-Cy7标记的新型分泌细胞表面蛋白/成骨细胞相关蛋白SCUBE3抗体
- 别 名
- CEGF3; CUB and EGF containing protein 3; CUB and EGF-like domain-containing protein 3; CUB domain and EGF like repeat containing 3; DKFZp686B09105; DKFZp686B1223; DKFZp686D20108; FLJ34743; OTTHUMP00000016250; SCUB3_HUMAN; SCUBE 3; SCUBE3; Signal peptide; Signal peptide CUB and EGF like domain containing protein 3; Signal peptide CUB domain EGF like 3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 发育生物学 信号转导 干细胞 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 107kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from Human SCUBE3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
SCUBE3 is a novel secreted 993 amino acid cell-surface osteoblast protein that plays an important role in bone cell biology. While highly expressed in osteoblasts, SCUBE3 expression is unobservable or very low in non-bone tissues. SCUBE3 forms homo-oligomers and hetero-oligomers with SCUBE1, and may undergo C-terminal proteolytic cleavage or become N-glycosylated following translation. Two SCUBE3 isoforms exist as a result of alternative splicing events. SCUBE3 contains one CUB domain and nine EGF-like domains, and is encoded by a gene which maps to human chromosome 6p21.31, a region associated with a rare form of metabolic bone disease known as Pagets disease. Chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome.
Function:
Binds to TGFBR2 and activates TGFB signaling. In lungcancer cells, could serve as an endogenous autocrine and paracrineligand of TGFBR2, which could regulate TGFBR2 signaling and hencemodulate epithelial-mesenchymal transition and cancer progression.
Subunit:
Forms homooligomers and heterooligomers with SCUBE1.Interacts with TGFBR2 through the CUB domain; this interaction doesnot affect TGFB1-binding to TGFBR2.
Subcellular Location:
Secreted. Cell surface.
Tissue Specificity:
Highly expressed in osteoblasts. Expression is low or absent in non-bone tissues.
Post-translational modifications:
N-glycosylated.
May undergo proteolytic cleavage in the C-terminal region.
Similarity:
Contains 1 CUB domain.
Contains 9 EGF-like domains.
Database links:Entrez Gene: 222663 Human
Entrez Gene: 268935 Mouse
Omim: 614708 Human
SwissProt: Q8IX30 Human
SwissProt: Q66PY1 Mouse
Unigene: 12923 Human
Unigene: 258491 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.