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货号： bs-12322R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12322R-PE-Cy7
- 英文名称
- Anti-Protein BOC/PE-Cy7
- 中文名称
- PE-Cy7标记的蛋白BOC抗体
- 别 名
- Boc homolog (mouse); Brother of CDO; Protein BOC; brother of CDO precursor; Protein BOC; BOC_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 发育生物学 神经生物学 干细胞 细胞表面分子 细胞膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Zebrafish, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 121kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Protein BOC
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
BOC is a receptor-like, single pass membrane protein belonging to the cell surface molecule subfamily of the Immunoglobulin/fibronectin type-III repeat family within the immunoglobulin superfamily. It contains three fibronectin type-III domains and four Immunoglobulin-like C2-type domains in its extracellular region. The intracellular region of BOC is not required for proper function. BOC localizes to the cell membrane and is ubiquitously expressed with highest expression levels in skeletal muscle and small intestine. Its mRNA expression is down-regulated by Ras. BOC is involved in accelerating myoblast differentiation and is dependent on CDO for its activity. BOC and CDO are co-expressed in muscle precursors and are components of a receptor complex that mediates cell-cell interactions important in myogenesis. Overexpression of BOC results in enhanced differentiation of myoblast cells. In addition, BOC is a target and signaling component of the Shh pathway.
Function:
Brother of CDO (BOC) interacts with Hedgehog (Hh) via a specific FNIII domain and belongs to the Ihog (interference hedgehog) family of proteins. Zebrafish BOC is expressed predominantly in the developing neural plate and later in the neural tube and developing brain.
Subunit:
Part of a complex that contains BOC, CDON, NEO1, cadherins and CTNNB1. Interacts with NTN3 (By similarity). Interacts with CDH2 and CTNNB1. Interacts with CDH15 only during the early stages of myoblast differentiation.
Subcellular Location:
Cell membrane; Single pass type I membrane protein. Note: Enriched at sites of cell-cell contact.
Tissue Specificity:
Detected in skeletal muscle, heart, thymus, kidney and small intestine. Detected at lower levels in brain, placenta, lung and colon mucosa.
Post-translational modifications:
N-glycosylated.
Similarity:
Contains 3 fibronectin type-III domains.
Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Database links:Entrez Gene: 512018Cow
Entrez Gene: 487979Dog
Entrez Gene: 100712740 Guinea pig
Entrez Gene: 100071428Horse
Entrez Gene: 91653Human
Entrez Gene: 117606Mouse
Entrez Gene: 100626085Pig
Entrez Gene: 100347510Rabbit
Entrez Gene: 360715Rat
Entrez Gene: 334628Zebrafish
Omim: 608708Human
SwissProt: Q9BWV1Human
SwissProt: Q6AZB0Mouse
Unigene: 591318Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.