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货号： bs-12286R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12286R-PE-Cy7
- 英文名称
- Anti-DDX3Y/PE-Cy7
- 中文名称
- PE-Cy7标记的精子发育相关蛋白DDX3Y抗体
- 别 名
- DBY; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3 Y linked; DEAD box protein 3 Y chromosomal; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide Y chromosome; DDX3Y_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 干细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 73kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from Human DDX3Y
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
DDX3X is encoded by a gene found on the X chromosome while DDX3Y is encoded by a gene on the Y chromosome. DDX3Y is exclusively expressed in testis and is required for normal spermatogenesis. DDX3X is ubiquitously expressed and predominantly localizes to the nuclear speckles, participating in RNA splicing, transcription, translation initiation, mRNA transport and cell cycle regulation. DDX3X also partakes in HIV-1 replication and hepatitis C viral infections.
Function:
DEAD box proteins are putative RNA helicases, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as ribosome and spliceosome assembly, translation initiation and nuclear and mitochondrial splicing. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome. Mutations in DDX3Y cause male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that it plays a key role in the spermatogenic process. Alternatively spliced variants, encoding the same protein, have been identified.
Subunit:
May interact with TDRD3.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Testis-specific. Expressed predominantly in spermatogonia.
DISEASE:
Note=DDX3Y is located in the azoospermia factor a (AZFa) region on chromosome Y which is deleted in Sertoli cell-only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia.
Similarity:
Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
Database links:
UniProtKB/Swiss-Prot: O15523.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.