产品中心
当前位置：首页>产品中心Anti-KCNT2/PE-Cy7
货号： bs-12177R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12177R-PE-Cy7
- 英文名称
- Anti-KCNT2/PE-Cy7
- 中文名称
- PE-Cy7标记的钙激活钾通道蛋白KCNT2抗体
- 别 名
- KCa4.2; Potassium channel, subfamily T, member 2; Sequence like an intermediate conductance potassium channel subunit; SLICK; SLO2.1; Sodium and chloride activated ATP sensitive potassium channel; Sodium and chloride activated ATP sensitive potassium channel Slo2.1; KCNT2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 通道蛋白 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 130kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human KCNT2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Voltage-gated K+ channels in the plasma membrane are important regulators of electrical signaling, controlling the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. KCNT2 is a 1,135 amino acid multi-pass transmembrane protein belonging to the potassium channel family (calcium-activated subfamily) of proteins. KCNT2 produces rapidly activating outward rectifier potassium currents in reponse to high intracellular sodium and chloride levels. Its channel activity is inhibited by ATP, inhalation anesthetics, such as isoflourane, and upon stimulation of G-protein coupled receptors, such as mAChR M1 and GluR-1. There are four isoforms of KCNT2 that are produced as a result of alternative splicing events.
Function:
KCNT2 belongs to the potassium channel family, calcium-activated subfamily and contains one RCK N-terminal domain. KCNT2 is an outward rectifying potassium channel and produces rapidly activating outward rectifier K(+) currents. It is activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane. KCNT2 is inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. There are four named isoforms.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Post-translational modifications:
Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity.
Similarity:
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily.
Contains 1 RCK N-terminal domain.
Database links:Entrez Gene: 343450 Human
Entrez Gene: 240776 Mouse
Entrez Gene: 304827 Rat
Omim: 610044 Human
SwissProt: Q6UVM3 Human
SwissProt: Q6UVM4 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.