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货号： bs-12145R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12145R-PE-Cy7
- 英文名称
- Anti-CART/PE-Cy7
- 中文名称
- PE-Cy7标记的卡因和安非他明调节转录蛋白抗体
- 别 名
- CART; CART prepropeptide; Cocaine and amphetamine regulated transcript; CART_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 转录调节因子 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 10kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CART
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The CART gene encodes for a protein which has an important role in the regulation of appetite and body weight. The CART (cocaine- and amphetamine-regulated transcript) neuropeptide is an mRNA that changes in response to psychostimulant drug administration. Injection of CART peptides into the ventral tegmental area produces psychostimulant-like effects. CART localizes to areas of the central and peripheral nervous systems and is involved in feeding behavior when injected centrally. Expression of CART in the rat hypothalamus is modulated by nutritional status, and injection of synthetic CART peptide into the forebrain ventricular system suppresses food intake, indicating a possible role in hypothalamic control of energy homeostasis. Its identification in cell bodies and central terminals of vagal afferent neurons additionally suggests a role in brainstem mechanisms of meal termination and satiety.
Function:
CART (Cocaine and amphetamine regulated transcript protein) is implicated in reward, feeding, and stress, and it has the functional properties of an endogenous psychostimulant. It is closely associated with the actions of leptin and neuropeptide Y. It promotes neuronal development and survival in vitro.
Subcellular Location:
Secreted
Tissue Specificity:
Hypothalamus. Found in neurons of the ventrolateral part of the arcuate nucleus, in the external zone of the median eminence, and also found in terminals in the periventricular part of the paraventricular nucleus.
Similarity:
Belongs to the CART family.
Database links:Entrez Gene: 9607 Human
Entrez Gene: 27220 Mouse
Entrez Gene: 29131 Rat
Omim: 602606 Human
SwissProt: Q16568 Human
SwissProt: P56388 Mouse
SwissProt: P49192 Rat
Unigene: 1707 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.