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货号： bs-12090R-PE-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12090R-PE-Cy7
- 英文名称
- Anti-Glycine Receptor alpha 1 + alpha 2/PE-Cy7
- 中文名称
- PE-Cy7标记的甘氨酸受体α1+甘氨酸受体α2抗体
- 别 名
- GLRA1+GLRA2; GLRA1; GLRA2; Glycine receptor 48 kDa subunit; Glycine receptor alpha 1; Glycine receptor alpha 2; Glycine receptor subunit alpha 1; Glycine receptor subunit alpha 2; Glycine receptor, alpha 1 subunit; Glycine receptor, alpha 2 subunit; STHE; GLRA1_HUMAN; GLRA2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 通道蛋白 细胞膜受体 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 49kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Glycine Receptor alpha 1 + alpha 2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Glycine receptors are members of the ligand-gated ion channel superfamily, which mediate fast inhibitory neurotransmission. The receptors are pentameric membrane proteins which form chloride channels. Binding of glycine to its receptor produces an increase in chloride conductance and membrane hyperpolarisation. Four genes encoding glycine receptor alpha subunits have been identified, together with a single beta polypeptide. Each subunit consists of a large extracellular N-terminal region, four transmembrane domains, and a large cytoplasmic domain.
Function:
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
Subunit:
Pentamer composed of alpha and beta subunits.
Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
DISEASE:
Defects in GLRA1 are the cause of hyperekplexia, hereditary, type 1 (HKPX1) [MIM:149400]. A neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.
Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.
Database links:Entrez Gene: 2741 Human
Entrez Gene: 2742 Human
Entrez Gene: 14654 Mouse
Entrez Gene: 237213 Mouse
Entrez Gene: 24397 Rat
Entrez Gene: 25674 Rat
Omim: 138491 Human
Omim: 305990 Human
SwissProt: P23415 Human
SwissProt: P23416 Human
SwissProt: Q6DJV9 Human
SwissProt: Q64018 Mouse
SwissProt: Q7TNC8 Mouse
SwissProt: P07727 Rat
SwissProt: P22771 Rat
Unigene: 121490 Human
Unigene: 2700 Human
Unigene: 113877 Mouse
Unigene: 358598 Mouse
Unigene: 10109 Rat
Unigene: 10379 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.